Asymmetric lithiation-substitution of amines involving rearrangement of borates.
نویسندگان
چکیده
Asymmetric lithiation of substituted benzylamines, N-Boc-pyrrolidine, or N-Boc-indoline using Beak's methodology was followed by electrophilic quench with trialkylboranes. The resulting borate intermediates rearrange with concomitant C-N bond breakage to give, after oxidation, chiral secondary alcohols with high enantioselectivity.
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ورودعنوان ژورنال:
- Organic letters
دوره 10 1 شماره
صفحات -
تاریخ انتشار 2008